TRAP-6

Not For Human Use, Lab Use Only.

C34H56N10O9

SKU KSP-25465 Category

Sequence 3 letters:

H-Ser-Phe-Leu-Leu-Arg-Asn-OH

Sequence:

SFLLRN

Cas No. :

Molecular Formula:

C34H56N10O9

Molecular Weight:

748.88 net

Description

SFLLRN corresponds to residues 42-47 of the thrombin receptor. The hexapeptide acts as a thrombin receptor activator. It caused half-maximal platelet aggregation at approx. 0.8 uM and was 5 times more potent than the parent peptide H-8105. In addition, SFLLRN is effective in causing tyrosine phosphorylation, inhibition of cAMP formation, and an increase in cytosolic Ca2+.

Reference

  • R.R.Vassallo, Jr. et al., J. Biol. Chem., 267, 6081 (1992)
  • L.F.Brass et al., J. Biol. Chem., 269, 2943 (1994)
  • R.Kaufmann et al., NeuroReport, 9, 709 (1998)
  • B.A.Olson et al., Pharmacology, 58, 200 (1999)
  • R.Kaufmann et al., J. Neurooncol., 42, 131 (1999)
  • H.Andersen et al., Proc. Natl. Acad. Sci. USA, 96, 11189 (1999)
  • C.-C.Wu et al., Br. J. Pharmacol., 130, 1289 (2000)
  • H.Shankar et al., Blood, 104, 1335 (2004)
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