Sequence 3 letters:

H-Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro-OH

Sequence:

H-THRPPMWSPVWP-OH

Cas No. :

Molecular Formula:

C₇₁H₉₉N₁₉O₁₅S

Molecular Weight:

1490.72

Description

Transferrin receptor (TfR), is a transmembrane glycoprotein involved in cellular iron trafficking after interaction with its native iron-rich ligand, transferrin (Tf). Of the two TfR subtypes, theTfR2 is abundantly expressed in glioblastomas and their associated vasculature. Using the M13-phage screening on chicken embryo fibroblasts constitutively expressing the human transferrin receptor (hTfR), peptides T7 (HAIYPRH) and T12 (THRPPMWSPVWP) were discovered. Both peptides have been widely used to target several cancer types overexpressing transferrin receptors (TfR1 and TfR2), including liver, prostate, breast, pancreatic cancers, and many others. T12 showed higher affinity, in nanomolar range, towards the target and appeared more promising than the T7 peptide. However, T12 failed to show enhanced transport of conjugated compounds across the BBB.

Reference

• Wängler, C. et al. Mol Imaging Biol doi: 10.1007/s11307-010-0329-6, (2010).