Sequence 3 letters:

H-Cys-Gly-Asn-Lys-Arg-Thr-Arg-OH

Sequence:

H-CGNKRTR-OH

Cas No. :

Molecular Formula:

C₃₁H₅₉N₁₅O₁₀S

Molecular Weight:

833.96

Description

The LyP-1 sequence (CGNKRTRGC) contains a cryptic CendR domain responsible for the tissue penetrating activity. The truncated variant of the LyP-1 peptide, tLyP- 1 (CGNKRTR), with exposed CendR domain showed more potent tumor homing and penetration than the parent peptide. In addition to NRP-1, the tLyP-1 also shows affinity towards NRP-2 to trigger cellular internalization via the CendR pathway.

Reference

• Roth L, Agemy L, Kotamraju VR, Braun G, Teesalu T, Sugahara KN, et al. Transtumoral targeting enabled by a novel neuropilin-binding peptide. Oncogene. 2012;31(33):3754-63