Sequence 3 letters:

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Tyr-Lys-Glu-Gly-Tyr-Asn-Val-Tyr-Gly-OH

Sequence:

H-YGRKKRRQRRRYKEGYNVYG-OH

Cas No. :

Molecular Formula:

C₁₁₅H₁₈₅N₄₃O₂₉

Molecular Weight:

2633.96

Description

The synthetic peptide (Tat-Glur23Y/Tat-GluA2-3Y/Tat-GluA2(3Y)) contains tyrosine residues that blocks phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. Previous research shows that Tat-Glur23Y blocks regulated AMPA and thereby prevents long-term depression (LTD) in structures such as the nucleus accumbens and dorsal hippocampus. Tat-GluA2-3Y peptide could competitively inhibits binding of Syt3 to a tyrosine-rich (3Y) motif on the cytoplasmic tail of GluA2. Injecting the Tat-GluA2-3Y peptide in wild-type mice mimics the lack of forgetting of spatial memories, and this effect is occluded in Syt3 knockout mice.

Reference

• Awasthi A, Ramachandran B, Ahmed S, et al. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science. 2019;363(6422)