Sequence 3 letters:

H-Arg-Phe-Cys-Trp-Lys-Val-Cys-Tyr-Lys-Gly-Ile-Cys-Phe-Lys-Lys-Cys-Lys-NH2

Sequence:

H-RFCWKVCYKGICFKKCK-NH2 (disulfide bridge: C3–C16, C7–C12)

Cas No. :

Molecular Formula:

C₉₉H₁₅₁N₂₇O₁₈S₄

Molecular Weight:

2135.68

Description

Candida did not develop resistance, under the specific experimental conditions used, against RP554, RP556, and RP557. RP557 exhibited broad-spectrum antifungal activity against 46 clinical isolates comprising fluconazole-sensitive and resistant strains of C. albicans, C. glabrata, C. tropicalis, and C. parapsilosis and intrinsically resistant C. krusei. RP557 is a potential therapeutic for the treatment of vulvovaginal candidiasis.

Reference

• Woodburn KW, Clemens LE, Jaynes J, et al. Designed Antimicrobial Peptides for Recurrent Vulvovaginal Candidiasis Treatment. Antimicrob Agents Chemother. 2019;63(11):e02690-18. Published 2019 Oct 22. doi:10.1128/AAC.02690-18