Sequence 3 letters:

H-Ala-Gly-Arg-Gly-Arg-Leu-Val-Arg-OH

Sequence:

H-AGRGRLVR-OH

Cas No. :

Molecular Formula:

C₃₆H₆₉N₁₇O₉

Molecular Weight:

884.04

Description

The Tenascin-C binding peptide PL3 (AGRGRLVR) is a CendR motif containing peptide. PL3 was identified by using the in vitro biopanning on recombinant Tenascin- C. PL3 functionalized iron oxide nanoworms (NW) or Ag-nanoparticles accumulated in the glioblastoma or pancreatic carcinoma xenografts in preclinical models and colocalized with Tenascin-C and NRP-1. In addition, treatment of glioblastoma-bearing mice with PL3-guided proapoptotic D(KLAKLAK)2-peptide containing NWs significantly inhibited tumor growth and prolonged the survival of the animals.

Reference

• Lingasamy P, Tobi A, Kurm K, Kopanchuk S, Sudakov A, Salumäe M, et al. Tumor-penetrating peptide for systemic targeting of Tenascin-C. Sci Rep. 2020;10(1):5809