Sequence 3 letters:

H-Trp-Trp-Trp-Ala-(Dab)-Tyr-Gly-Leu-(Dab)-Leu-Leu-(Dab)-Tyr-(Dab)-(Dab)-Trp-Tyr-OH

Sequence:

H-WWWA(Dab)YGL(Dab)LL(Dab)Y(Dab)(Dab)WY-OH

Cas No. :

Molecular Formula:

C₁₀₉H₁₃₅N₂₁O₂₁

Molecular Weight:

2260.61

Description

PepW binding to capsule and the subsequent structure loss leads to capsule-peptide aggregation that distorts or removes the capsule, allowing the remaining free peptide to disrupt the bacterial membrane . This mechanism for antimicrobial peptide activity toward capsulated K. pneumoniae offers a ray of light in the fight for effective therapeutics toward this extremely resistant species.

Reference

• Fleeman RM, Macias LA, Brodbelt JS, Davies BW. Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27620-27626. doi: 10.1073/pnas.2007036117. Epub 2020 Oct 21. PMID: 33087568; PMCID: PMC7959497.