Sequence 3 letters:

H-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2

Sequence:

PAEDLARYYSALRHYINLITRQRY

Cas No. :

Molecular Formula:

C₁₃₅H₂₀₉N₄₁O₃₆

Molecular Weight:

2982.4 net

Description

This fragment is able to compete with the intact NPY for essentially all binding sites in rat brain. However, it is less potent than the native peptide in its NPY-receptor binding affinity.

Reference

• M.W.Walker and R.J.Miller, Mol. Pharmacol., 34, 779 (1988)
• J.L.Krstenansky et al., Proc. Natl. Acad. Sci. USA, 86, 4377 (1989)
• D.R.Gehlert et al., Neurochem. Int., 21, 45 (1992)