Sequence 3 letters:

H-Ser-Gln-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2

Sequence:

SQAFLFQPQRF

Cas No. :

Molecular Formula:

C₆₅H₉₄N₁₈O₁₅

Molecular Weight:

1367.57

Description

This anti-opiate neuropeptide has been implicated in pain modulation as well as in opioid tolerance and may play a critical role in this process. For the neuropeptide Y-like human orphan G protein-coupled receptor HLWAR77 this peptide exhibited an EC50 value of 0.39 nM. Furthermore, it has been shown to modulate a variety of physiological processes such as food intake, insulin release, blood pressure regulation and electrolyte balance. Please see also also our anorexigenic

Reference

• S.J.Perry et al., FEBS Lett., 409, 426 (1997)
• N.A.Elshourbagy et al., J. Biol. Chem., 275, 25965 (2000)