Sequence 3 letters:

H-Glu-Ile-Gly-Asp-Glu-Glu-Asn-Ser-Ala-Lys-Phe-Pro-Ile-Gly-Arg-Arg-Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln-Val-OH

Sequence:

EIGDEENSAKFPIGRRDFDMLRCMLGRVYRPCWQV

Cas No. :

Molecular Formula:

C₁₈₂H₂₈₂N₅₄O₅₂S₄

Molecular Weight:

4186.84

Description

Neuropeptide EI-Gly-Arg-Arg-MCH (human, mouse, rat) has been shown to be more potent in stimulating feeding in the rat than MCH (H-1482) following intracerebroventricular administration although it did not exhibit better agonist activity in in vitro assays. Its enhanced activity in feeding behaviour compared to MCH might be due to its reduced susceptibility to proteolytic degradation by MCH-degrading enzymes such as endopeptidase 24.11 and aminopeptidase M.

Reference

• A.Viale et al., J. Biol. Chem., 274, 6536 (1999)
• L.Maulon-Feraille et al., J. Pharmacol. Exp. Ther., 302, 766 (2002)