Sequence 3 letters:

H-Ala-Gly-Glu-Gly-Leu-Asn-Ser-Gln-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2

Sequence:

AGEGLNSQFWSLAAPQRF

Cas No. :

Molecular Formula:

C₉₀H₁₃₂N₂₆O₂₅

Molecular Weight:

1978.2

Description

This anti-opiate neuropeptide has been implicated in pain modulation as well as in opioid tolerance and may play a critical role in this process. For the neuropeptide Y-like human orphan G protein-coupled receptor HLWAR77 this peptide exhibited an EC50 value of 1.26 nM. Furthermore, it has been shown to modulate a variety of physiological processes such as food intake, insulin release, blood pressure regulation and electrolyte balance. Please see also also our anorexigenic

Reference

• S.J.Perry et al., FEBS Lett., 409, 426 (1997)
• N.A.Elshourbagy et al., J. Biol. Chem., 275, 25965 (2000)
• I.Lefrere et al., J. Biol. Chem., 277, 39169 (2002)