Sequence 3 letters:

H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2

Sequence:

YPSKPDNPGEDAPAEDLARYYSALRHYINLLTRPRY

Cas No. :

Molecular Formula:

C₁₉₀H₂₈₆N₅₄O₅₆

Molecular Weight:

4222.69

Description

This NPY analog is a highly potent and selective ligand for Y1 receptors in different cell lines and tissues. It has therefore been used to detect the NPY/PYY receptor subtype distribution, e.g., in rat brain. The peptide is also active in vivo, showing an even higher potency than NPY in increasing blood pressure in anesthetized rats.

Reference

• J.Fuhlendorff et al., Proc. Natl. Acad. Sci. USA, 87, 182 (1990)
• D.R.Gehlert et al., Neurochem. Int., 21, 45 (1992)