Sequence 3 letters

H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH₂ (Disulfide bond: 2-7)

Sequence

H-KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2 (Disulfide bond: 2-7)

Cas No.

121381-06-4

Molecular Formula

C₁₆₅H₂₆₀N₅₀O₅₆S₂

Molecular Weight

3903.2

Purity

95%+ by HPLC

Description

The amyloidogenic peptide hormone amylin 1-37 (or Islet Amyloid Polypeptide, IAPP), KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY amide, has been isolated from the amyloid-rich pancreases of diabetic patients. IAPP forms fibrillar peptide deposits in the pancreatic islets of Langerhans, which may be related to death of the insulin-producing islet β-cells in type 2 diabetes mellitus.

Reference