Sequence 3 letters:

H-Glu-Leu-Asp-Arg-Ile-Cys-Gly-Tyr-Gly-Thr-Ala-Arg-Cys-Arg-Lys-Lys-Cys-Arg-Ser-Gln-Glu-Tyr-Arg-Ile-Gly-Arg-Cys-Pro-Asn-Thr-Tyr-Ala-Cys-Cys-Leu-Arg-Lys-OH

Sequence:

H-ELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRK-OH(Disulfide bonds between Cys6-Cys33, Cys13-Cys27, and Cys17-Cys34)

Cas No. :

Molecular Formula:

C₁₈₀H₂₉₅N₆₃O₅₂S₆

Molecular Weight:

4366.03

Description

Synthetic hBD-4 exhibits a selective, salt-sensitive spectrum of antimicrobial activity, and it represents one of the most active antimicrobial peptides against Pseudomonas aeruginosa (minimal inhibitory concentration: 4.1 μg/ml) known to date. This defensin is chemotactic for human blood monocytes, but it is inactive on neutrophils and eosinophils.

Reference

• García JR, Krause A, Schulz S, Rodríguez-Jiménez FJ, Klüver E, Adermann K, et al. Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity.