Sequence 3 letters:

H-Pro-Leu-Gly-Tyr(Br)-Met(O)-Phe-Arg-OH

Sequence:

PLGY(Br)M(O)FR

Cas No. :

Molecular Formula:

C₄₂H₆₁BrN₁₀O₁₀S

Molecular Weight:

978.0

Description

Four holokinins have been isolated from A. japonicus: holokinin-1 (PLGYMFR) and derivatives of holokinin-1 with either an oxidised methionine residue (PLGYM(O)FR, holokinin-2) or with a brominated tyrosine residue (PLGY(Br)MFR, holokinin-3) or with N-terminal truncation (GYMFR, holokinin-1(3–7)). All four peptides cause inhibition of electrically induced contraction of radial longitudinal muscle (RLM) preparations and contraction of intestine preparations.

Reference

• Elphick MR. The protein precursors of peptides that affect the mechanics of connective tissue and/or muscle in the echinoderm Apostichopus japonicus. PLoS One. 2012;7(8):e44492. doi:10.1371/journal.pone.0044492