Sequence 3 letters:

H-Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH

Sequence:

H-ACYCRIPACIAGERRYGTCIYQGRLWAFCC-OH(Disulfide bridge: 2-30, 4-19, 9-29)

Cas No. :

Molecular Formula:

C₁₅₀H₂₂₂N₄₄O₃₈S₆

Molecular Weight:

3442.01

Description

Mammalian defensins are abundant in the cytoplasmic azurophilic granules of neutrophils, Paneth cells of the small intestine and some macrophages. Human a-defensin-1 (HNP-1) is a peptide possessing both broad antimicrobial (both Gram-positive and Gram-negative bacteria) and cytotoxic activities. HNP-1 reduces adenoviral infection by more than 95%.

Reference

• T. Ganz et al., J. Clin. Invest., 76, 1427 (1985);
• M.E. Selsted et al., J. Clin. Invest., 76, 1436 (1985);
• T. Ganz et al., Eur. J. Haematol, 44, 1 (1990)