Sequence 3 letters:

H-His-Arg-Leu-Arg-Tyr-NH2

Sequence:

HRLRY

Cas No. :

Molecular Formula:

C₃₃H₅₄N₁₄O₆

Molecular Weight:

742.88

Description

The inactive NPY carboxy-terminal pentapeptide (IC50 > 100 uM) was modified by replacing threonine with histidine and glutamine with leucine. The resulting peptide had a dramatically improved affinity (IC50 = 0.45 uM) for the rat brain receptor.

Reference

• A.J.Daniels et al., Mol. Pharmacol., 48, 425 (1995)