[Gln22] -β- Amyloid (1-40)
Not For Human Use, Lab Use Only.
(Gln22)β-Amyloid (1-40) human is an amyloid beta protein (Aβ)-containing peptide used in Alzheimer’s disease research.
Sequence 3 letters
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gln-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
Sequence
H-DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVV-OH
Cas No.
/
Molecular Formula
C194H296N54O57S
Molecular Weight
4328.91
Purity
95%+ by HPLC
Description
The Dutch mutation (E22Q) of amyloid β-peptide aggregates more readily than the wild-type peptide and the resulting fibrils show increased neurotoxicity. The mutant peptide E22Q induced apoptosis of cerebral endothelial cells at a concentration of 25 μm, whereas WT Aβ 1-40 and the Italian mutant E22K (H-6698) showed no effect.
Reference
[1]. Kirkitadze MD, et al. Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis. J Mol Biol. 2001 Oct 5;312(5):1103-19.