[Gln22] -β- Amyloid (1-40)

Not For Human Use, Lab Use Only.

(Gln22)β-Amyloid (1-40) human is an amyloid beta protein (Aβ)-containing peptide used in Alzheimer’s disease research.

SKU KSP-10701 Category

Sequence 3 letters

H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gln-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

Sequence

H-DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVV-OH

Cas No.

  /

Molecular Formula

C194H296N54O57S

Molecular Weight

4328.91

Purity

95%+ by HPLC

Description

The Dutch mutation (E22Q) of amyloid β-peptide aggregates more readily than the wild-type peptide and the resulting fibrils show increased neurotoxicity. The mutant peptide E22Q induced apoptosis of cerebral endothelial cells at a concentration of 25 μm, whereas WT Aβ 1-40 and the Italian mutant E22K (H-6698) showed no effect.

Reference

[1]. Kirkitadze MD, et al. Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis. J Mol Biol. 2001 Oct 5;312(5):1103-19.

Categories:
Product Quote Form
Please enable JavaScript in your browser to complete this form.
Name
Email