Sequence 3 letters:

Pyroglutamic acid Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2

Sequence:

Pyr-GPWLEEEEEAYGWMDF-NH2

Cas No. :

Molecular Formula:

C₉₇H₁₂₄N₂₀O₃₁S

Molecular Weight:

2098.19

Description

Gastrin-1 is also referred to as Gastrin-17 or “Little Gastrin.” Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stomach. Secreted by the G cells in the gastric mucosa, it is one of the major bioactive forms of gastrin found in tissue and plasma (the other bioactive form is Gastrin-34 or Big Gastrin – Cat# AS-20747). Both Gastrin-17 and Gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of Gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor. Binding of Gastrin to the CCK2/Gastrin receptors on parietal cells of the stomach causes them to secrete hydrochloric acid (HCl) and stimulates lectin-like protein Reg expression via activation of PKC and RhoA. Gastrin also plays a role in release of Histamine and Pepsinogen.

Reference

• Choudhury, A. et al. Hoppe-Seylers Z Physiol Chem 361, 1719 (1980)
• Niederle, B. Wien Klin Wochenschr 119, 561 (2007), doi: 10.1007/s00508-007-0897-x.
• O’Connor A. et. al. Digestive Dis 32, 186 (2014), doi: 10.1159/000357848
• Dockray, G. et.al. Pflügers Archiv 449,344 (2005)
• Bundgaard, JR et al. J Biol Chem 272, 21700 (1997), doi: 10.1074/jbc.272.35.21700
• Yakabi, K. et al. World J Gastroenterol 14, 6334 (2008), doi: 10.3748/wjg.14.6334