Sequence 3 letters:

H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2

Sequence:

GWTLNSAGYLLGPRHYINLITRQRY

Cas No. :

Molecular Formula:

C₁₃₆H₂₀₉N₄₁O₃₄

Molecular Weight:

2962.41

Description

This chimeric peptide is a high affinity galanin receptor antagonist (IC50= 0.1 nM in rat hypothalamus membranes and Kd= 0.01 nM in rat spinal cord membranes). This peptide is also recognized by neuropeptide Y receptors (IC50= 0.25 uM in rat cerebral cortex membranes).

Reference

• K.Arvidsson et al., Biochemistry, 32, 7787 (1993)
• U.Kahl et al., Br. J. Pharmacol., 111, 1129 (1994)
• X.-J.Xu et al., Br. J. Pharmacol., 116, 2076 (1995)