Sequence 3 letters:

H-Trp-Lys-Arg-Ile-Val-Arg-Arg-Ile-Lys-Arg-Trp-Leu-Arg-NH2

Sequence:

H-WKRIVRRIKRWLR-NH2 (Amidation)

Cas No. :

Molecular Formula:

C₈₇H₁₄₉N₃₃O₁₃

Molecular Weight:

1865.32

Description

FK-13-a1 and FK-13-a7 was 6.3- and 2.3-fold that of parental LL-37, respectively. Furthermore, FK-13-a1 and FK-13-a7 displayed more potent antimicrobial activity against antibiotic-resistant bacteria including MRSA, MDRPA, and VREF, than did LL-37

Reference

• Rajasekaran G, Kim EY, Shin SY. LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity. Biochim Biophys Acta Biomembr. 2017 May;1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037. Epub 2017 Feb 1. PMID: 28161291.