Sequence 3 letters:

H-Gly-Ile-Phe-Ser-Lys-Leu-Ala-Gly-Lys-Lys-Ile-Lys-Asn-Leu-Leu-Ile-Ser-Gly-Leu-Lys-Gly-Amidation

Sequence:

H-GIFSKLAGKKIKNLLISGLKG-Amidation

Cas No. :

Molecular Formula:

C₁₀₂H₁₈₂N₂₈O₂₄

Molecular Weight:

2184.7

Description

Esculentin 1-21(Esc(1–21)), a linear antimicrobial peptide from frog skin with inhibitory effect on bovine mastitis-causing bacteria. This peptide (i) is highly potent against the most common mastitis-causing microbes (e.g. Streptococcus agalactiae); and (ii) is active in vivo, causing a visible regression of the clinical stage of mastitis in dairy cows, after 1 week of peptide treatment. Biophysical characterisation revealed that the peptide adopts an alpha-helical structure in microbial mimicking membranes and is able to permeate the membrane of S. agalactiae in a dose-dependent manner. Overall, Esc(1-21) as an attractive AMP for the future design of new antibiotics to cure mastitis in cattle.

Reference

• Islas-Rodru00ecguez AE, Marcellini L, Orioni B, Barra D, Stella L, Mangoni ML. Esculentin 1-21: a linear antimicrobial peptide from frog skin with inhibitory effect on bovine mastitis-causing bacteria. J Pept Sci. 2009;15(9):607-14