Sequence 3 letters:

H-Pro-Met-Lys-Lys-Leu-Lys-Leu-Ala-Leu-Arg-Leu-Ala-Ala-Lys-Ile-Ala-Pro-Val-Trp-OH

Sequence:

H-PMKKLKLALRLAAKIAPVW-OH

Cas No. :

Molecular Formula:

C₁₀₃H₁₇₉N₂₇O₂₀S

Molecular Weight:

2147.75

Description

The computationally generated peptide, EcDBS1R5 (PMKKLKLALRLAAKIAPVW), inspired by an E. coli AMP, was active at 8 μmol L−1 against P. aeruginosa in in vitro assays, while in a skin scarification mouse model infected by P. aeruginosa, the same peptide was active only at a concentration 8-fold higher (64 μmol L−1), even though the concentration was lower than its cytotoxic activity (>128 μmol L−1).

Reference

• Cardoso, M. H., Cândido, E. S., Chan, L. Y., Der Torossian Torres, M., Oshiro, K. G. N., Rezende, S. B., Porto, W. F., Lu, T. K., de la Fuente-Nunez, C., Craik, D. J., and Franco, O. L. A (2018) Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies. ACS Infect. Dis. 4, 1727−1736.