Sequence 3 letters:

H-Val-Gln-Trp-Arg-Ala-Ile-Arg-Val-Arg-Val-Ile-Arg-NH2 (d-amino acids)

Sequence:

H-VQWRAIRVRVIR-NH2 (d-amino acids)

Cas No. :

Molecular Formula:

C₇₀H₁₂₃N₂₇O₁₃

Molecular Weight:

1550.89

Description

DJK-5 (vqwrairvrvir; d-amino acids) and DJK-6 (vqwrrirvw-vir; d-amino acids) were identified from screening a library of 12-amino-acid-long peptides with the following design constraints: d-enantiomeric forms of only 9 amino acids (A, F, I, K, L, Q, R, V, W), 4 charged residues, 7–8 hydrophobic residues, and 0–1 Q residues. DJK-5 and DJK-6 were identified as being able to inhibit biofilm formation by several common bacterial strains, at concentrations below their MIC, and to eradicate established biofilms. Further, DJK-5 was shown to decrease abscess size and reduce bacterial burden in a mouse cutaneous abscess model induced by P. aeruginosa.

Reference

• Mansour, S. C., Pletzer, D., de la Fuente-Núñez, C., Kim, P., Cheung, G. Y. C., Joo, H.-S., Otto, M., and Hancock, R. E. W. (2016) Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically. EBioMedicine 12, 219−226.
• Kłodzińska, S. N., Pletzer, D., Rahanjam, N., Rades, T., Hancock, R. E. W., and Nielsen, H. M. (2019) Hyaluronic Acid-Based Nanogels Improve in vivo Compatibility of the Anti-Biofilm Peptide DJK-5. Nanomedicine 20, 102022.