Sequence 3 letters:

H-Asp-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH

Sequence:

H-DCYCRIPACIAGERRYGTCIYQGRLWAFCC-OH(Disulfide bridge: 2-30,4-19,9-29)

Cas No. :

Molecular Formula:

C₁₅₁H₂₂₂N₄₄O₄₀S₆

Molecular Weight:

3486.02

Description

This peptide contain 6 conserved disulfide-linked cysteines. In vitro, it has a prominent antimicrobial activities against bacteria, fungi, and certain enveloped viruses. In addition, human and rabbit defensins exert potent cytotoxicity in vitro against various mammalian tumor cells.

Reference

• P.A.Raj et al., Biochem. J., 347, 633 (2000)
• F.T.Lundy et al., Oral Oncol., 40, 139 (2004)
• Z.Wu et al., J. Pept. Res., 64, 118 (2004)