Sequence 3 letters

cyclo-(Arg-Ala-Asp-D-Phe-Lys)

Sequence:

c(RADfK)

Cas No.

756500-23-9

Molecular Formula

C28H43N9O7

Molecular Weight

617.6971

Purity

95%+ by HPLC

Description

An RGD tumor-targeting peptide, which binds to αvβ3 receptors. c(RADfK) can be easily conjugated to fluorophore tags, chelators, or carriers. Palecek et al. converted the ε-amino group into the azide by diazo transfer allowing further functionalization by click chemistry. Mercapto groups can be introduced via acylation of c(RADfK) with S-acetylthioacetic acid (SATA).

In Vitro

Cyclo(RADfK) is a negative control for the cyclo (-RGDfK-), the RGD peptide. RGD peptides are modulators of cell adhesion and are recognized by several members of the integrin family

References

[1]. Srivatsan A, et al. Conjugation of cRGD peptide to chlorophyll a based photosensitizer (HPPH) alters its pharmacokinetics withenhanced tumor-imaging and photosensitizing (PDT) efficacy. Mol Pharm. 2011 Aug 1;8(4):1186-1197