Atrial Natriuretic Factor (1-28) (human)

Not For Human Use, Lab Use Only.

C127H203N45O39S3

SKU KSP-25540 Category

Sequence 3 letters:

H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH

Sequence:

SLRRSSCFGGRMDRIGAQSGLGCNSFRY

Cas No. :

Molecular Formula:

C127H203N45O39S3

Molecular Weight:

3080.49 net

Description

ANP/ANF is synthesized in cardiac myocytes and is primarily released in response to atrial wall stretching and intravascular volume expansion. The peptide signals via the guanylate cyclase-linked natriuretic peptide receptor A (NPR-A) and plays an important role in blood pressure regulation and blood volume homeostasis. ANP/ANF exerts vasodilatory, diuretic, natriuretic, anti-inflammatory, antifibrotic and antimitogenic effects.

Reference

  • S.Mukaddam-Daher, Expert Opin. Ther. Targets, 10, 239 (2006)
  • G.M.Felker et al., CMAJ, 175, 611 (2006)
  • S.Rubattu et al., Am. J. Hypertens., 21, 733 (2008)
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