Sequence 3 letters:

Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe

Sequence:

SEVNLDAEF

Cas No. :

Molecular Formula:

C₄₄H₆₆N₁₀O₁₈

Molecular Weight:

1023.07

Description

SEVNLDAEF corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer’s disease, therefore referred to as the ‘Swedish’ mutation (K670N/M671L). The peptide has been used for assaying cleavage at leucine-aspartate by cathepsin G and chymotrypsin, whereas neither cathepsin B, D nor L generated any products.

Reference