Sequence 3 letters:

H-Gly-Ile-Lys-Ala-Lys-Ile-Ile-Ile-Lys-Ile-Lys-Lys-Amidation

Sequence:

H-GIKAKIIIKIKK-Amidation

Cas No. :

Molecular Formula:

C₆₅H₁₂₆N₁₈O₁₂

Molecular Weight:

1351.8

Description

The antimicrobial peptide zp37 (GIKAKIIIKIKK-NH2), which possesses a helical structure, was found to exhibit a minimum inhibitory concentration (MIC) value of 16 μM on E. coli O157:H7, effectively killing such strain in vitro and reducing its population size by 94.7% in sprouts upon storage for seven days. In sprouts, zp37 treatment reduced 94.7% E. coli O157:H7 upon storage for 7 days. zp37 caused membrane depolarization and weak membrane permeabilization. zp37 bound to the DNA of E. coli O157:H7, causing DNA aggregation and precipitation.

Reference

• Lanhua Yi, Ping Zeng, Jun Liu, Kwok-Yin Wong, Edward Wai-Chi Chan, Yanbing Lin, Kin-Fai Chan, Sheng Chen. Antimicrobial peptide zp37 inhibits Escherichia coli O157:H7 in alfalfa sprouts by inflicting damage in cell membrane and binding to DNA, LWT, Volume 146, 2021, 111392, ISSN 0023-6438