Sequence 3 letters:

Ile-Ser-Tyr-Gly-Asn-Asp-Ala-Leu-Met-Pro

Sequence:

ISYGNDALMP

Cas No. :

Molecular Formula:

C₄₇H₇₃N₁₁O₁₆S

Molecular Weight:

1080.23

Description

Amyloid β/A4 Protein Precursor₇₇₀ (586-595) (human, mouse, rat) also known as APP-derived inhibitory peptide (APP-IP), efficiently inhibited the activity of gelatinase A (matrix metalloproteinase-2 (MMP-2)) (IC₅₀ = 30 nM), whereas its inhibitory activity towards membrane type 1-matrix metalloproteinase was much weaker (IC₅₀ = 2 µM). The decapeptide ISYGNDALMP had poor inhibitory activity towards gelatinase B, matrilysin or stromelysin (IC₅₀ > 10 µM). APP-IP is likely an active site-directed inhibitor of gelatinase A. Clarification of its mode of action might provide a lead for the design of novel anti-cancer drugs that block specific processes of tumor invasion and angiogenesis.

Reference