Sequence 3 letters:

H-Ala-Phe-Thr-Cys-His-Cys-Arg-Arg-Ser-Cys-Tyr-Ser-Thr-Glu-Tyr-Ser-Tyr-Gly-Thr-Cys-Thr-Val-Met-Gly-Ile-Asn-His-Arg-Phe-Cys-Cys-Leu-OH

Sequence:

H-AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL-OH(Disulfide bonds between Cys4- Cys31, Cys6- Cys20, and Cys10- Cys30)

Cas No. :

Molecular Formula:

C₁₅₆H₂₂₈N₄₆O₄₆S₇

Molecular Weight:

3708.2

Description

Cysteine-rich cationic peptide with antiviral activity against HSV infection and a role in N. gonorrhoeae-mediated HIV enhancement. In contrast to the other members of the ƒ-defensin family it shows very low antimicrobial activity against Gram-negative and Gram-positive bacteria. As a biomarker of colon adenocarcinoma it may have utility in colon cancer screening and diagnosis.

Reference

• Z.Wu et al., J. Pept. Res., 64, 118 (2004)
• M.J.Nam et al., J. Biol. Chem., 280, 8260 (2005)
• E.Hazrati et al., J. Immunol., 177, 8658 (2006)
• A.Szyk et al., Protein Sci., 15, 2749 (2006)
• M.E.Klotman et al., J. Immunol., 180, 6176 (2008)