Sequence 3 letters:

Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe

Sequence:

YEVHHQKLVFF

Cas No. :

Molecular Formula:

C₇₁H₉₉N₁₇O₁₆

Molecular Weight:

1446.68

Description

The amyloid precursor protein (APP) is cleaved within the amyloid β-protein region by a putative APP secretase to release its extracellular portion. Gelatinase A, the matrix metalloproteinase MMP-2, possesses such APP secretase-like activity, effectively hydrolyzing also the synthetic amyloid β-protein fragment (10-20) YEVHHQKLVFF at the normal processing site, the Lys¹⁶-Leu¹⁷ bond (Km approx. 0.13 mM).

Reference