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PEG-Based Liner for PROTAC

Introduction  Proteolysis targeting chimeras (PROTACs) are an interesting type of hetero-bivalent compounds that attach and bring together the target and the E3 enzyme concurrently to enhance the ubiquitination of a target protein. These compounds comprise three structural elements: a linker that joins the two ligands, one of which binds the protein of interest (POI) and the…

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PROTAC Linkers and their role in developing cancer therapeutics

Introduction  Novel approaches are always being sought in the dynamic field of cancer therapies to tackle the difficulties presented by historically elusive pharmacological targets. A novel strategy that is gaining popularity is the application of Proteolysis-Targeting Chimeras (PROTACs). These molecules have shown tremendous promise in the selective degradation of disease-causing proteins, providing novel therapeutic options…

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