March 2024

PEG-Based Liner for PROTAC

Introduction  Proteolysis targeting chimeras (PROTACs) are an interesting type of hetero-bivalent compounds that attach and bring together the target and the E3 enzyme concurrently to enhance the ubiquitination of a target protein. These compounds comprise three structural elements: a linker that joins the two ligands, one of which binds the protein of interest (POI) and the…

Read article